Seminal fluid anaphylaxis

Results A 54 year-old woman with no atopic history was referred for evaluation after four progressive episodes of post-coital reactions with her husband. The first two episodes consisted of itching of both palms and soles of feet with minimal vaginal pruritus. After abstaining, a third episode a month later consisted of hives on the patient’s legs and back with significant vaginal pruritus. The fourth episode the patient developed vaginal and generalized pruritus, urticaria, palpitations and trouble breathing through her nose, immediately post-coital. All symptoms resolved spontaneously with no treatment. Skin prick testing was conducted using the partner’s seminal fluid to confirm the clinical suspicion of SFA, producing a wheal of 8mm and flare of 5cm.